Non-clinical safety of GRAd vector-based COVID-19 and HIV vaccines supports a platform regulatory approach
#HIV vaccines#GRAd vector-based#Non-clinical safety#GRAd platform#mandated non-clinical
Life Science News
Latest updates from the biotech and pharma world
A programmable mRNA platform for miRNA detection via miRNA-mRNA2 triplex-mediated ribosomal frameshifting
#frameshifting Programmed#ribosomal frameshifting#recoding mechanism#mechanism utilized#coding capacity
Characterization of a new laboratory colony of Anopheles funestus mosquitoes established in Ifakara, Tanzania
#Tanzania Background#funestus#Anopheles funestus#FUMOZ colonies#Tanzania
Sex-biased duplicates are rapidly generated during Drosophila tRNA repertoire evolution
#evolution Eukaryotic#transfer RNA#Eukaryotic genomes#RNA genes#efficient translation
Bacillus competence pili are efficient single - and double stranded DNA uptake machines
#stranded DNA#DNA#Natural competence#machines Natural#host chromosome
Antiviral and anti-inflammatory effects of Tabamide A derivative, TA25, against human rhinovirus and multiple zoonotic viruses in vitro and in silico
#human rhinovirus#family Piconaviridae#silico Human#HRV#human
General-Purpose Large Language Models, such as DeepSeek V3.2, Have Evolved Protein Design Capabilities
#Language Models#Large Language#language processing#General-Purpose Large#natural language
Lignin degradation and valorization by Pseudomonas putida KT2440: a new role for glutathione peroxidase
#poses significant#industrial applications#Pseudomonas putida#complex natural#Lignin degradation
Histones and nucleoid-associated proteins in Methanosarcina acetivorans mediate recovery from stress and stasis
#nucleoid-associated proteins#Binding Proteins#DNA Binding#proteins#archaeal DNA
Biophysical constraints on mRNA decay rates shape macroevolutionary divergence in steady-state abundances
#major driver#divergence#Evolutionary#rates#phenotypic divergence
Flavobacteria buffer nitrous oxide emissions from partial denitrifiers in coastal sediments
#nitrous oxide#partial denitrifiers#potent greenhouse#nitrous#oxide
Glycerol suppresses lactose-dependent growth of Streptococcus pyogenes through a transcription-independent mechanism
#Streptococcus pyogenes#Streptococcus#mechanism Streptococcus#requires flexible#host environments
HIV Virion Capturing Liposomes for Therapeutic Vaccination
#Virion Capturing#Vaccination HIV#Therapeutic Vaccination#Capturing Liposomes#antiretroviral treatments
An ancient anthozoan protein reveals an alternative evolutionary path of antiviral signaling
#evolutionary biology#alternative evolutionary#evolutionary path#anthozoan protein#central question
Bacteriophage genome-wide transposon mutagenesis
#Bacteriophage genome-wide#mutagenesis Bacteriophages#size range#coding sequences#unknown function
The RNA-binding protein RBM39 scaffolds an m⁶A-dependent RNA decay complex that destabilizes Tat transcripts and restricts HIV-1 reactivation
#Minghua Chen#Cancan Chen#Jiaye Liu#Bingfeng Liu#Siyi Xie
Cardiac, respiratory, and gastric rhythms independently modulate motor corticospinal excitability in humans
#Teresa Schuhmann#Tahnée Engelen#Catherine Tallon-Baudry#Tallon-Baudry Interoception#Interoception refers
A framework to determine active neurons and networks within the mouse brain reveals how brain activity changes over the course of the day
#Tomoyuki Mano#Shoi Shi#Erica Pedron#Konstantinos Kompotis#Guanhua Sun
Beyond the buzz: Grounding interoceptive interventions in mechanisms of brain–body coupling
#Teresa Berther#Martina Saltafossi#Jana Fehring#Joachim Gross#Grounding interoceptive
Oxytocin neurons drive melanocortin circuit maturation via vesicle release during a neonatal critical period
#Fabienne Schaller#Soyoung Park#Emilie Caron#Jessica Klucznik#Phillipe Ciofi