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Triplets electrically turn on insulating lanthanide-doped nanoparticles
Nature, Published online: 19 November 2025; doi:10.1038/s41586-025-09601-yTo turn on and obtain emission from lanthanide-doped insulating nanoparticles, an electrical e...
A skin-permeable polymer for non-invasive transdermal insulin delivery
Nature, Published online: 19 November 2025; doi:10.1038/s41586-025-09729-xThe fast skin-permeable polyzwitterion poly[2-(N-oxide-N,N-dimethylamino)ethyl methacrylate] m...
Electro-generated excitons for tunable lanthanide electroluminescence
Nature, Published online: 19 November 2025; doi:10.1038/s41586-025-09717-1The electroluminescence emitted from lanthanide fluoride nanocrystals functionalized with liga...
Rewiring an olfactory circuit by altering cell-surface combinatorial code
Nature, Published online: 19 November 2025; doi:10.1038/s41586-025-09769-3In Drosophila, changing the expression of a small set of cell-surface proteins in just one typ...
Hepatic zonation determines tumorigenic potential of mutant β-catenin
Nature, Published online: 19 November 2025; doi:10.1038/s41586-025-09733-1Zonal positioning in the liver determines whether the CTNNB1 oncogene can induce liver cancer.
Tumour-reactive heterotypic CD8 T cell clusters from clinical samples
Nature, Published online: 19 November 2025; doi:10.1038/s41586-025-09754-wTumour-reactive CD8+ T cells are enriched in functional clusters with tumour cells and/or anti...
Integrator dynamics in the cortico-basal ganglia loop for flexible motor timing
Nature, Published online: 19 November 2025; doi:10.1038/s41586-025-09778-2How the mouse frontal cortex and striatum interact to implement integrator dynamics controllin...
Structural basis of regulated N-glycosylation at the secretory translocon
Nature, Published online: 19 November 2025; doi:10.1038/s41586-025-09756-8The structural mechanism of a natively isolated GRP94 folding intermediate tethered to a CCDC1...
Repulsions instruct synaptic partner matching in an olfactory circuit
Nature, Published online: 19 November 2025; doi:10.1038/s41586-025-09768-4Transcriptomic screening identifies pairs of cell-surface proteins that mediate repulsive inte...
Insulin cream offers needle-free option for diabetes
Nature, Published online: 19 November 2025; doi:10.1038/d41586-025-03803-0Skin-permeable polymer shows promise at insulin delivery in animal experiments — plus, how the...
Semantic design of functional de novo genes from a genomic language model
Nature, Published online: 19 November 2025; doi:10.1038/s41586-025-09749-7By learning a semantics of gene function based on genomic context, the genomic language model...
Prime editing-installed suppressor tRNAs for disease-agnostic genome editing
Nature, Published online: 19 November 2025; doi:10.1038/s41586-025-09732-2A new strategy that uses prime editing to convert an endogenous tRNA into a suppressor tRNA sh...
Author Correction: A metallic <i>p</i>-wave magnet with commensurate spin helix
Nature, Published online: 19 November 2025; doi:10.1038/s41586-025-09861-8Author Correction: A metallic p-wave magnet with commensurate spin helix
ZAK activation at the collided ribosome
Nature, Published online: 19 November 2025; doi:10.1038/s41586-025-09772-8The kinase ZAK is activated at collided ribosomes to mediate the ribotoxic stress response.
The Asymmetric Synthesis of an Acyclic <i>N</i>-Stereogenic Amine
Nature, Published online: 19 November 2025; doi:10.1038/s41586-025-09905-zThe Asymmetric Synthesis of an Acyclic N-Stereogenic Amine
Connectivity underlying motor cortex activity during goal-directed behaviour
Nature, Published online: 19 November 2025; doi:10.1038/s41586-025-09758-6All-optical mapping of neural connectivity in motor cortex links network topology to network d...
Author Correction: AIM2 in regulatory T cells restrains autoimmune diseases
Nature, Published online: 19 November 2025; doi:10.1038/s41586-025-09859-2Author Correction: AIM2 in regulatory T cells restrains autoimmune diseases
A brain implant that could rival Neuralink’s enters clinical trials
Nature, Published online: 20 November 2025; doi:10.1038/d41586-025-03849-0Neurotechnology company Paradromics will test its device in a trial aimed at safely restoring...