星形胶质细胞通过特化叶片状结构功能性地整合多个突触
Astrocytes functionally integrate multiple synapses via specialized leaflet domains
#Lucas Benoit#Ines Hristovska#Nicolas Liaudet#Arnold Fertin#Milica Jevtic
生命科学资讯
生物技术与制药领域的最新动态
线粒体活性调节伤害感受器对兴奋毒性的耐受能力
Mitochondrial activity tunes nociceptor resilience to excitotoxicity
#Lin Yuan#David Julius#Publication date#November#Cell
一种从纤毛中回收多聚泛素化蛋白的保守机制
A conserved mechanism for the retrieval of polyubiquitinated proteins from cilia
#Alan Brown#Publication date#November#Cell#Volume
番茄中受体拮抗剂平衡多种系统素植物细胞因子
A receptor antagonist counterbalances multiple systemin phytocytokines in tomato
#Nga Pham#Andreas Schaller#Judith Fliegmann#Matthias Erb#Thomas Boller
立体测序V2：实现福尔马林固定石蜡包埋切片中总RNA的高分辨率空间定位
Stereo-seq V2: Spatial mapping of total RNA on FFPE sections with high resolution
#Xinya Zhang#Xin Huang#Mei Yang#Jing Guo#Tingting Cao
基于长读长宏基因组学的非培养元泛基因组学揭示与儿童营养不良的关联
Culture-independent meta-pangenomics enabled by long-read metagenomics reveals associations with pediatric undernutrition
#Nicholas Allsing#Kenneth Maleta#Nolan Hartwick#Allen Mamerto#Caitriona Brennan
孕期与哺乳期肝细胞代谢适应性变化
Hepatocyte metabolic adaptations during pregnancy and lactation
#Liu Yang#Yu-Heng Zhou#Tong-Yun Mao#Qi-Qi Zheng#Hou-Zao Chen
人类中疫苗诱导异源HIV-1中和抗体B细胞谱系
Vaccine induction of heterologous HIV-1-neutralizing antibody B cell lineages in humans
#Gilad Ofek#Nathaniel Erdmann#Kshitij Wagh#Bette Korber#Katayoun Mansouri
从猛犸象遗骸中获取的古老宿主相关微生物
Ancient host-associated microbes obtained from mammoth remains
#Benjamin Guinet#Nikolay Oskolkov#Kelsey Moreland#Marianne Dehasque#Anders Angerbjörn
公共卫生监测忽视的哺乳动物间病原体与抗生素耐药基因广泛跨物种传播
Extensive cross-species transmission of pathogens and antibiotic resistance genes in mammals neglected by public health surveillance
#Yuqi Shi#Ayidana Haerheng#Philippe Lemey#Jia Tang#Publication date
结核分枝杆菌转录调控进化与传播增强及耐药性相关
Evolution of Mycobacterium tuberculosis transcription regulation is associated with increased transmission and drug resistance
#Qingyun Liu#Roger Calderon#Leonid Lecca#Maxine Caws#Phan Vuong
AI仿效实验科学揭示细菌进化关键基因转移机制
AI mirrors experimental science to uncover a mechanism of gene transfer crucial to bacterial evolution
#Juraj Gottweis#Alexander Daryin#Anil Palepu#Artiom Myaskovsky#Annalisa Pawlosky
嵌合感染颗粒扩展噬菌体诱导染色体岛动员的物种界限
Chimeric infective particles expand species boundaries in phage-inducible chromosomal island mobilization
#Jinlong Wang#Laura Miguel-Romero#Publication date#November#Cell
SNARE蛋白在巨自噬过程中不可或缺
SNARE Proteins Are Required for Macroautophagy
#Usha Nair#Anjali Jotwani#Jiefei Geng#Noor Gammoh#Diana Richerson
黏膜病毒感染通过1型滤泡辅助T细胞引发长效IgA反应
Mucosal viral infection elicits long-lived IgA responses via type 1 follicular helper T cells
#Kei Haniuda#Yuko Makita#Sandhya Appiah#Thamotharampillai Dileepan#Publication date
靶向巨噬细胞的免疫细胞因子利用髓样细胞、T细胞和NK细胞协同作用进行癌症免疫治疗
Macrophage-targeted immunocytokine leverages myeloid, T, and NK cell synergy for cancer immunotherapy
#Pascale Zwicky#Ken Xie#Fadi Sheban#Adam Yalin#Florian Uhlitz
阐明用于阿尔茨海默病治疗的路径选择性偏向CCKBR激动作用
Elucidating pathway-selective biased CCKBR agonism for Alzheimer’s disease treatment
#Yue Shao#Hui Lin#Jie Cheng#Pan Shang#Fan Yang
脑磁图：用于解读非编码变异的功能基因组学图谱
BRAIN-MAGNET: A functional genomics atlas for interpretation of non-coding variants
#Ruizhi Deng#Elena Perenthaler#Anita Nikoncuk#Soheil Yousefi#Kristina Lanko
单细胞对病毒感染的易感性受可变细胞状态驱动
Single-cell susceptibility to viral infection is driven by variable cell states
#Sam Reffsin#Jesse Miller#Kasirajan Ayyanathan#Yael Heyman#Naveen Jain
抑制血红素生物合成引发急性髓系白血病中的铜死亡现象
Inhibition of heme biosynthesis triggers cuproptosis in acute myeloid leukemia
#Emily Gruber#Rheana Franich#Jessica Armstrong#Léa Flippe#Kevin Wijanarko