生命科学资讯
生物技术与制药领域的最新动态
Shifting the PPARγ conformational ensemble toward a transcriptionally repressive state improves covalent inhibitor efficacy
发育信号中的反共振调控细胞命运决策
Anti-resonance in developmental signaling regulates cell fate decisions
<i>cxcl18b</i>定义的过渡态特异性一氧化氮驱动斑马鱼视网膜损伤诱导的穆勒胶质细胞周期再进入
cxcl18b-defined transitional state-specific nitric oxide drives injury-induced Müller glia cell-cycle re-entry in the zebrafish retina
Ω-环突变通过调节PDC-3 β-内酰胺酶的氢键网络控制活性位点动力学
Ω-Loop mutations control dynamics of the active site by modulating the hydrogen-bonding network in PDC-3 β-lactamase
在大鼠骨关节炎模型中鉴定出具有增强治疗效果的滑膜间充质干细胞亚群
Identification of a sub-population of synovial mesenchymal stem cells with enhanced treatment efficacy in a rat model of osteoarthritis
ATAD2介导染色质结合组蛋白伴侣的周转
ATAD2 mediates chromatin-bound histone chaperone turnover
新皮层微细与中尺度回路建模与仿真(第一部分:解剖学)
Modeling and simulation of neocortical micro- and mesocircuitry (Part I, anatomy)
新皮质微细与中尺度神经回路建模与仿真(第二部分,生理学与实验研究)
Modeling and simulation of neocortical micro- and mesocircuitry (Part II, Physiology and experimentation)
小梁网单细胞分析揭示青光眼模型中线粒体功能障碍,维生素B3治疗可提供保护作用。
Single-cell profiling of trabecular meshwork identifies mitochondrial dysfunction in a glaucoma model that is protected by vitamin B3 treatment
GMCL1调控53BP1稳定性并调节紫杉烷敏感性
GMCL1 controls 53BP1 stability and modulates taxane sensitivity
CCR5内吞作用中arrestin2相互作用的高分辨率分析
A high-resolution analysis of arrestin2 interactions responsible for CCR5 endocytosis
通过个体性迁移预测跨任务条件下的人类决策
Predicting human decision-making across task conditions via individuality transfer
神经元-胶质细胞相互作用与寿命的关联
Linking neuron-glia interactions and longevity
胶质细胞<i>betaPix</i>对斑马鱼大脑血管发育至关重要
Glial betaPix is essential for blood vessel development in the zebrafish brain
COVID-19患者唾液病毒脱落模式的分层分析
Stratification of viral shedding patterns in saliva of COVID-19 patients
靶向计算设计白细胞介素-7超级因子,提升折叠效率与免疫治疗效果
Targeted computational design of an interleukin-7 superkine with enhanced folding efficiency and immunotherapeutic efficacy
生物信息启发的皮层模型预测光遗传学扰动
Biologically informed cortical models predict optogenetic perturbations
超越合规,以《研究人员发展协约》为基础
Going beyond compliance to build on the Researcher Development Concordat
Rtf1依赖性转录暂停调控心脏发生
Rtf1-dependent transcriptional pausing regulates cardiogenesis