构建高效中心代谢途径，提升酵母生物合成能力且不抑制细胞生长
Creating an energy efficient central metabolism for boosting biosynthesis without compromising cell growth of yeast
#cell growth#Long-term natural#compromising cell#rapid cell#yeast Long-term
生命科学资讯
生物技术与制药领域的最新动态
地热变形虫刷新真核生物生存温度上限
A geothermal amoeba sets a new upper temperature limit for eukaryotes
#temperature limit#upper temperature#geothermal amoeba#largely focused#amoeba sets
针对代谢弱点：缬氨霉素增强生物能量抑制剂对抗耐药与休眠结核分枝杆菌的效力
Targeting Metabolic Vulnerabilities: Valinomycin Augments the Potency of Bioenergetic Inhibitors in Combatting Drug-Resistant and Dormant Mycobacterium tuberculosis
#Metabolic Vulnerabilities#Dormant Mycobacterium#Mycobacterium tuberculosis#Combatting Drug-Resistant#Valinomycin Augments
转录组学与蛋白质组学分析揭示氮循环是原绿球藻长期生存的核心机制
Transcriptomic and Proteomic Analysis Reveals Nitrogen Recycling as a Core Mechanism for Prochlorococcus Prolonged Survival
#Core Mechanism#Reveals Nitrogen#Nitrogen Recycling#Prolonged Survival#Analysis Reveals
高致病性禽流感A(H5)病毒分支2.3.2.1c和2.3.4.4持续进化导致血凝素基因分支命名更新
Nomenclature updates to the hemagglutinin gene clade designations resulting from the continued evolution of high pathogenicity avian influenza A(H5) virus clades 2.3.2.1c and 2.3.4.4
#high pathogenicity#pathogenicity avian#avian influenza#Nomenclature updates#merit nomenclature
人类星状病毒中病毒蛋白酶介导的多聚蛋白加工
Viral protease-mediated polyprotein processing in human astroviruses
#Positive-sense RNA#RNA viruses#astroviruses Positive-sense#encode large#proteolytically processed
揭示公共与私有T细胞受体识别肽的结构决定因素
Uncovering structural determinants of peptide recognition by public and private T-cell receptors
#private T-cell#Uncovering structural#structural determinants#common pathogens#incompletely defined
仲裁系统通过调控小抗阻遏蛋白来控制裂解/溶原性决策
Arbitrium systems control lysis/lysogeny through the regulation of small antirepressor proteins
#temperate Bacillus#Bacillus phages#Arbitrium systems#control lysis#Arbitrium
热与非热应激条件激活恶性疟原虫AP2-HS依赖性热休克反应
Thermal and non-thermal stress conditions activate the Plasmodium falciparum AP2-HS-dependent heat-shock response
#Plasmodium falciparum#HSR#heat shock#chaperone-encoding genes#conserved heat
石胆酸诱导依赖T3SS形成具有侵袭能力的福氏志贺氏菌聚集物
Lithocholic acid induces T3SS-dependent formation of invasion-competent Shigella flexneri aggregates
#invasion-competent Shigella#Shigella flexneri#Shigella#deaths worldwide#aggregates Shigella
基于口腔微生物组的食管鳞状细胞癌跨大陆普适性预测模型
A generalizable cross-continent prediction of esophageal squamous cell carcinoma using the oral microbiome
#esophageal squamous#squamous cell#cell carcinoma#poor prognosis#microbiome Esophageal
博物馆收藏的Diadema Antillarum中盾纤毛虫检测与微生物组构成分析
Scuticociliate Detection and Microbiome Composition in Museum Collections of Diadema Antillarum
#Diadema Antillarum#Antillarum Background#Microbiome Composition#Scuticociliatosis Philaster-clade#antillarum Scuticociliatosis
针对牛病原体莫拉氏菌的新型噬菌体特性研究
Characterisation of novel bacteriophages against the cattle pathogen Moraxella bovis
#bovis Background#Infectious bovine#Moraxella bovis#pathogen Moraxella#disease worldwide
基于GRAd载体的新冠与HIV疫苗的非临床安全性支持平台监管策略
Non-clinical safety of GRAd vector-based COVID-19 and HIV vaccines supports a platform regulatory approach
#HIV vaccines#GRAd vector-based#Non-clinical safety#GRAd platform#mandated non-clinical
基于miRNA-mRNA2三链体介导核糖体移码的可编程mRNA平台用于miRNA检测
A programmable mRNA platform for miRNA detection via miRNA-mRNA2 triplex-mediated ribosomal frameshifting
#frameshifting Programmed#ribosomal frameshifting#recoding mechanism#mechanism utilized#coding capacity
坦桑尼亚伊法卡拉新建立的富氏按蚊实验室种群特征研究
Characterization of a new laboratory colony of Anopheles funestus mosquitoes established in Ifakara, Tanzania
#Tanzania Background#funestus#Anopheles funestus#FUMOZ colonies#Tanzania
果蝇tRNA库进化中性别偏向性重复快速产生
Sex-biased duplicates are rapidly generated during Drosophila tRNA repertoire evolution
#evolution Eukaryotic#transfer RNA#Eukaryotic genomes#RNA genes#efficient translation
芽孢杆菌感受态菌毛是高效摄取单链和双链DNA的机制
Bacillus competence pili are efficient single - and double stranded DNA uptake machines
#stranded DNA#DNA#Natural competence#machines Natural#host chromosome
TA25——塔巴胺A衍生物在体外及计算机模拟中对人鼻病毒及多种人畜共患病毒的抗病毒与抗炎作用研究
Antiviral and anti-inflammatory effects of Tabamide A derivative, TA25, against human rhinovirus and multiple zoonotic viruses in vitro and in silico
#human rhinovirus#family Piconaviridae#silico Human#HRV#human
通用大语言模型如DeepSeek V3.2已进化出蛋白质设计能力
General-Purpose Large Language Models, such as DeepSeek V3.2, Have Evolved Protein Design Capabilities
#Language Models#Large Language#language processing#General-Purpose Large#natural language