人类中疫苗诱导异源HIV-1中和抗体B细胞谱系
Vaccine induction of heterologous HIV-1-neutralizing antibody B cell lineages in humans
#Gilad Ofek#Nathaniel Erdmann#Kshitij Wagh#Bette Korber#Katayoun Mansouri
生命科学资讯
生物技术与制药领域的最新动态
从猛犸象遗骸中获取的古老宿主相关微生物
Ancient host-associated microbes obtained from mammoth remains
#Benjamin Guinet#Nikolay Oskolkov#Kelsey Moreland#Marianne Dehasque#Anders Angerbjörn
公共卫生监测忽视的哺乳动物间病原体与抗生素耐药基因广泛跨物种传播
Extensive cross-species transmission of pathogens and antibiotic resistance genes in mammals neglected by public health surveillance
#Yuqi Shi#Ayidana Haerheng#Philippe Lemey#Jia Tang#Publication date
结核分枝杆菌转录调控进化与传播增强及耐药性相关
Evolution of Mycobacterium tuberculosis transcription regulation is associated with increased transmission and drug resistance
#Qingyun Liu#Roger Calderon#Leonid Lecca#Maxine Caws#Phan Vuong
AI仿效实验科学揭示细菌进化关键基因转移机制
AI mirrors experimental science to uncover a mechanism of gene transfer crucial to bacterial evolution
#Juraj Gottweis#Alexander Daryin#Anil Palepu#Artiom Myaskovsky#Annalisa Pawlosky
嵌合感染颗粒扩展噬菌体诱导染色体岛动员的物种界限
Chimeric infective particles expand species boundaries in phage-inducible chromosomal island mobilization
#Jinlong Wang#Laura Miguel-Romero#Publication date#November#Cell
SNARE蛋白在巨自噬过程中不可或缺
SNARE Proteins Are Required for Macroautophagy
#Usha Nair#Anjali Jotwani#Jiefei Geng#Noor Gammoh#Diana Richerson
黏膜病毒感染通过1型滤泡辅助T细胞引发长效IgA反应
Mucosal viral infection elicits long-lived IgA responses via type 1 follicular helper T cells
#Kei Haniuda#Yuko Makita#Sandhya Appiah#Thamotharampillai Dileepan#Publication date
靶向巨噬细胞的免疫细胞因子利用髓样细胞、T细胞和NK细胞协同作用进行癌症免疫治疗
Macrophage-targeted immunocytokine leverages myeloid, T, and NK cell synergy for cancer immunotherapy
#Pascale Zwicky#Ken Xie#Fadi Sheban#Adam Yalin#Florian Uhlitz
阐明用于阿尔茨海默病治疗的路径选择性偏向CCKBR激动作用
Elucidating pathway-selective biased CCKBR agonism for Alzheimer’s disease treatment
#Yue Shao#Hui Lin#Jie Cheng#Pan Shang#Fan Yang
脑磁图：用于解读非编码变异的功能基因组学图谱
BRAIN-MAGNET: A functional genomics atlas for interpretation of non-coding variants
#Ruizhi Deng#Elena Perenthaler#Anita Nikoncuk#Soheil Yousefi#Kristina Lanko
单细胞对病毒感染的易感性受可变细胞状态驱动
Single-cell susceptibility to viral infection is driven by variable cell states
#Sam Reffsin#Jesse Miller#Kasirajan Ayyanathan#Yael Heyman#Naveen Jain
抑制血红素生物合成引发急性髓系白血病中的铜死亡现象
Inhibition of heme biosynthesis triggers cuproptosis in acute myeloid leukemia
#Emily Gruber#Rheana Franich#Jessica Armstrong#Léa Flippe#Kevin Wijanarko
抑制寡聚BAX的抗凋亡二聚体作用
Inhibition of oligomeric BAX by an anti-apoptotic dimer
#Haleh Alimohamadi#Publication date#oligomeric BAX#dimer Publication#November
人类血管类器官发育过程中的命运与状态转变
Fate and state transitions during human blood vessel organoid development
#Makiko Seimiya#Gustav Jonsson#Wuji Cao#Ryo Okuda#Ryoko Okamoto
已灭绝猛犸象的古代RNA表达谱
Ancient RNA expression profiles from the extinct woolly mammoth
#Bastian Fromm#Nikolay Oskolkov#Zoé Pochon#Marianne Dehasque#Morteza Aslanzadeh
药物扰动下营养竞争预测肠道微生物组重构
Nutrient competition predicts gut microbiome restructuring under drug perturbations
#Handuo Shi#Sylvie Estrela#Juan Sanchez#Qinglin Zeng#Publication date
制药业面临向最高法院提起IRA诉讼的最后期限，首批议定价格即将出台
Pharma faces deadline to bring IRA fight to Supreme Court as first set of negotiated prices looms
辉瑞mRNA流感疫苗三期数据显示其效力比标准疫苗高出34.5%
Pfizer's mRNA flu vaccine shows 34.5% greater efficacy than standard shot in phase 3
#mRNA flu#Pfizer mRNA#flu vaccine#greater efficacy#greater effectiveness
疾控中心更新网站称疫苗可能引发自闭症，但无新证据支持
CDC updates website to say vaccines may cause autism without new evidence
#CDC updates#updates website#webpage undercut#medical community#community consensus