进展性多发性硬化症患者中的抗BCMA CAR-T疗法
Anti-BCMA CAR-T therapy in patients with progressive multiple sclerosis
#Chuan Qin#Jun Xiao#Wei Wang#Gerd Meyer#Ming-Hao Dong
生命科学资讯
生物技术与制药领域的最新动态
大豆基因组图谱揭示：8,105份种质资源的逐步驯化、全球传播与改良路径
Genomic atlas of 8,105 accessions reveals stepwise domestication, global dissemination, and improvement trajectories in soybean
#Zhou Zhu#Chao Fang#Xiaoyue Yang#Shuhui Song#Yalin Wang
Shank3寡聚化调控突触后密度凝聚体材料特性与突触可塑性
Shank3 oligomerization governs material properties of the postsynaptic density condensate and synaptic plasticity
#Bowen Jia#Zeyu Shen#Shihan Zhu#Jingguo Huang#Zhitao Liao
星形胶质细胞通过特化叶片状结构功能性地整合多个突触
Astrocytes functionally integrate multiple synapses via specialized leaflet domains
#Lucas Benoit#Ines Hristovska#Nicolas Liaudet#Arnold Fertin#Milica Jevtic
线粒体活性调节伤害感受器对兴奋毒性的耐受能力
Mitochondrial activity tunes nociceptor resilience to excitotoxicity
#Lin Yuan#David Julius#Publication date#November#Cell
一种从纤毛中回收多聚泛素化蛋白的保守机制
A conserved mechanism for the retrieval of polyubiquitinated proteins from cilia
#Alan Brown#Publication date#November#Cell#Volume
番茄中受体拮抗剂平衡多种系统素植物细胞因子
A receptor antagonist counterbalances multiple systemin phytocytokines in tomato
#Nga Pham#Andreas Schaller#Judith Fliegmann#Matthias Erb#Thomas Boller
立体测序V2：实现福尔马林固定石蜡包埋切片中总RNA的高分辨率空间定位
Stereo-seq V2: Spatial mapping of total RNA on FFPE sections with high resolution
#Xinya Zhang#Xin Huang#Mei Yang#Jing Guo#Tingting Cao
基于长读长宏基因组学的非培养元泛基因组学揭示与儿童营养不良的关联
Culture-independent meta-pangenomics enabled by long-read metagenomics reveals associations with pediatric undernutrition
#Nicholas Allsing#Kenneth Maleta#Nolan Hartwick#Allen Mamerto#Caitriona Brennan
孕期与哺乳期肝细胞代谢适应性变化
Hepatocyte metabolic adaptations during pregnancy and lactation
#Liu Yang#Yu-Heng Zhou#Tong-Yun Mao#Qi-Qi Zheng#Hou-Zao Chen
人类中疫苗诱导异源HIV-1中和抗体B细胞谱系
Vaccine induction of heterologous HIV-1-neutralizing antibody B cell lineages in humans
#Gilad Ofek#Nathaniel Erdmann#Kshitij Wagh#Bette Korber#Katayoun Mansouri
从猛犸象遗骸中获取的古老宿主相关微生物
Ancient host-associated microbes obtained from mammoth remains
#Benjamin Guinet#Nikolay Oskolkov#Kelsey Moreland#Marianne Dehasque#Anders Angerbjörn
公共卫生监测忽视的哺乳动物间病原体与抗生素耐药基因广泛跨物种传播
Extensive cross-species transmission of pathogens and antibiotic resistance genes in mammals neglected by public health surveillance
#Yuqi Shi#Ayidana Haerheng#Philippe Lemey#Jia Tang#Publication date
结核分枝杆菌转录调控进化与传播增强及耐药性相关
Evolution of Mycobacterium tuberculosis transcription regulation is associated with increased transmission and drug resistance
#Qingyun Liu#Roger Calderon#Leonid Lecca#Maxine Caws#Phan Vuong
AI仿效实验科学揭示细菌进化关键基因转移机制
AI mirrors experimental science to uncover a mechanism of gene transfer crucial to bacterial evolution
#Juraj Gottweis#Alexander Daryin#Anil Palepu#Artiom Myaskovsky#Annalisa Pawlosky
嵌合感染颗粒扩展噬菌体诱导染色体岛动员的物种界限
Chimeric infective particles expand species boundaries in phage-inducible chromosomal island mobilization
#Jinlong Wang#Laura Miguel-Romero#Publication date#November#Cell
SNARE蛋白在巨自噬过程中不可或缺
SNARE Proteins Are Required for Macroautophagy
#Usha Nair#Anjali Jotwani#Jiefei Geng#Noor Gammoh#Diana Richerson
黏膜病毒感染通过1型滤泡辅助T细胞引发长效IgA反应
Mucosal viral infection elicits long-lived IgA responses via type 1 follicular helper T cells
#Kei Haniuda#Yuko Makita#Sandhya Appiah#Thamotharampillai Dileepan#Publication date
靶向巨噬细胞的免疫细胞因子利用髓样细胞、T细胞和NK细胞协同作用进行癌症免疫治疗
Macrophage-targeted immunocytokine leverages myeloid, T, and NK cell synergy for cancer immunotherapy
#Pascale Zwicky#Ken Xie#Fadi Sheban#Adam Yalin#Florian Uhlitz
阐明用于阿尔茨海默病治疗的路径选择性偏向CCKBR激动作用
Elucidating pathway-selective biased CCKBR agonism for Alzheimer’s disease treatment
#Yue Shao#Hui Lin#Jie Cheng#Pan Shang#Fan Yang