by Yoshiko M. Ikushima, Kuan-Chan Chen, Richard J. Sulston, Domenico Mattiucci, Eleanor J. Brain, Stefanie A. Fung Xin Zi, Karla J. Suchacki, Benjamin J. Thomas, Andrea Lovdel, Matthew Bennett, Hiroshi Kobayashi, Phillip D. Whitfield, Keiyo Takubo, Andrew H. Baker, Nicholas M. Morton, Robert K. Semple, William P. Cawthorn Adiponectin is the most abundant hormone in the circulation. Plasma adiponectin decreases in obesity but increases in leanness, including during caloric restriction (CR) in animals and humans. In obesity, adiponectin deficiency promotes cardiometabolic dysfunction. In contrast, the roles of adiponectin in CR, when it is at its highest, are largely unknown. To address this, we studied global adiponectin knockout (KO) in male and female mice fed either ad libitum (AL) or a 30% CR diet from 9–13 weeks of age. We show that adiponectin KO did not alter CR effects on body mass, body composition, or energy expenditure. However, KO unexpectedly decreased blood glucose levels