Biopharma and med-tech happenings, including deals and partnerships, and other news in brief: AC Immune,   Aptose, Astrazeneca, Bioreference Health, Cardioline, Cardios, Filament Health, Guardant, Maxxspine Innovative, Mintneuro, Motif, Nuvalent, Osartis, OSR, Pinetree, Red Light Holland, Takeda, Vaximm, Wellspect.