PLoS Biology November 25, 2025

Cardiometabolic health and physical robustness map onto distinct patterns of brain structure and neurotransmitter systems

by Eliana Nicolaisen-Sobesky, Somayeh Maleki Balajoo, Mostafa Mahdipour, Agoston Mihalik, Mahnaz Olfati, Felix Hoffstaedter, Janaina Mourao-Miranda, Masoud Tahmasian, Simon B. Eickhoff, Sarah Genon The link between brain health and risk/protective factors for non-communicable diseases (such as high blood pressure, high body mass index, diet, smoking, physical activity, etc.) is increasingly acknowledged. However, the specific effects that these factors have on brain health are still poorly unde