PLoS Biology November 25, 2025

Efficient and reliable spike sorting from neural recordings with UMAP-based unsupervised nonlinear dimensionality reduction

by Daniel Suárez-Barrera, Lucas Bayones, Norberto Encinas-Rodríguez, Sergio Parra, Viktor Monroy, Sebastián Pujalte, Bernardo Andrade-Ortega, Héctor Díaz, Manuel Alvarez, Antonio Zainos, Alessio Franci, Román Rossi-Pool Spike sorting is one of the cornerstones of extracellular electrophysiology. By leveraging advanced signal processing and data analysis techniques, spike sorting makes it possible to detect, isolate, and map single neuron spiking activity from both in vivo and in vitro extracell