PLoS Biology November 25, 2025

Bacterial immune systems as causes and consequences of microbiome structure

by Rafael Custodio, Ellinor O. Alseth, Michael A. Brockhurst, Sam P. Brown, Edze R. Westra Attacks from molecular parasites such as mobile genetic elements (MGEs) have driven the evolution of defense systems in bacterial genomes. Yet, despite significant advances in understanding the molecular mechanisms of these bacterial immune systems, we have only a rudimentary understanding of their ecology and evolution. Bacteria exist as part of complex microbiomes, but community ecology and microbiome r