PLoS Biology November 25, 2025

Transient frontopolar cortex stimulation induces prolonged disruption to counterfactual processing

by Matthew Ainsworth, Juan M. Galeazzi, Carlos Pedreira, Mark G. Stokes, Mark J. Buckley Frontopolar cortex (FPC) contains area 10, an anterior sub-region of prefrontal cortex exclusive to humans and nonhuman primates (NHPs) which is thought to support monitoring the value of switching between alternative goals. However, the neuronal mechanisms underlying this function are unclear. Here, we used multielectrode arrays to record the local field potentials (LFPs) in the FPC of two macaques perform