bioRxiv November 25, 2025

General-Purpose Large Language Models, such as DeepSeek V3.2, Have Evolved Protein Design Capabilities

General-Purpose Large Language Models (GLLMs), although primarily developed for natural language processing, are increasingly demonstrating emergent capabilities in specialized scientific domains. In this study, we explored the potential of GLLMs, specifically DeepSeek V3.2 Exp in reasoning mode, to perform practical protein engineering tasks without domain-specific biological training. Two representative design problems were addressed: Generation of amino acid sequences predicted to adopt the c