Cell2Spatial是一种计算框架，可将单细胞映射至空间转录组位点，以重建组织结构。
by Huamei Li, Jingchao Liu, Guige Wang, Zhenyu Liu, Meng Cao, Lingyun Sun, Cheng Peng, Yiyao Liu, Liang Ma, Qing Xiong Single-cell (SC) sequencing enables detai...
by Huamei Li, Jingchao Liu, Guige Wang, Zhenyu Liu, Meng Cao, Lingyun Sun, Cheng Peng, Yiyao Liu, Liang Ma, Qing Xiong
Single-cell (SC) sequencing enables detailed characterization of transcriptional heterogeneity but lacks spatial context, while spatial transcriptomics (ST) preserves tissue organization yet is limited by resolution and incomplete gene capture. To bridge these gaps, we developed Cell2Spatial, a computational framework that segments spatial spots at single-cell resolution, even