生命科学资讯
生物技术与制药领域的最新动态
Accessibility of the unstructured α-tubulin C-terminal tail is controlled by microtubule lattice conformation
体内自发荧光寿命成像揭示果蝇蘑菇体空间代谢异质性及学习诱导变化
In vivo autofluorescence lifetime imaging of spatial metabolic heterogeneities and learning-induced changes in the Drosophila mushroom body
抗Aβ抗体的聚集依赖性表位序列与修饰指纹图谱
Aggregation-dependent epitope sequence and modification fingerprints of anti-Aβ antibodies
小鼠感觉运动皮层在伸抓过程中反映复杂的运动学细节
Mouse sensorimotor cortex reflects complex kinematic details during reaching and grasping
西酞普兰通过调节C5aR1<sup>+</sup> TAMs展现免疫依赖性抗肿瘤效应
Citalopram exhibits immune-dependent anti-tumor effects by modulating C5aR1+ TAMs
小鼠骨骼肌卫星细胞利用肌腱生成基因<i>Scleraxis</i>指导再生
Mouse skeletal muscle satellite cells co-opt the tenogenic gene Scleraxis to instruct regeneration
重新定义感觉运动皮层的边界
Redefining borders in the sensorimotor cortex
糖酵解依赖性硫代谢调控真菌形态可塑性与毒力
Glycolysis-dependent sulfur metabolism orchestrates morphological plasticity and virulence in fungi
单一微小RNA miR-195可挽救由EBF1缺陷引起的B细胞发育停滞
A single microRNA miR-195 rescues the arrested B cell development induced by EBF1 deficiency
通过小分子调节TFAM抑制干扰素信号通路
Suppression of interferon signaling via small-molecule modulation of TFAM
异时转录因子表达驱动十三纹地松鼠视锥细胞主导视网膜发育
Heterochronic transcription factor expression drives cone-dominant retina development in 13-lined ground squirrels
Ly6G<sup>+</sup>粒细胞来源的IL-17限制宿主保护性反应并促进结核病发病机制
Ly6G+ granulocytes-derived IL-17 limits protective host responses and promotes tuberculosis pathogenesis
背腹介导的<i>Shh</i>诱导是蝾螈肢体再生所必需的
Dorsoventral-mediated Shh induction is required for axolotl limb regeneration
更正:Gq活性与β-arrestin-1支架介导的ADGRG2/CFTR偶联对男性生育能力至关重要
Correction: Gq activity- and β-arrestin-1 scaffolding-mediated ADGRG2/CFTR coupling are required for male fertility
ZFT是弓形虫中铁和锌的主要转运蛋白
ZFT is the major iron and zinc transporter in Toxoplasma gondii
一款高分辨率、易搭建的光片显微镜,专用于亚细胞成像。
A high-resolution, easy-to-build light-sheet microscope for subcellular imaging
X射线照射后果蝇翅盘单细胞转录组学揭示与细胞周期状态和细胞位置相关的异质性。
Single-cell transcriptomics of X-ray irradiated Drosophila wing discs reveals heterogeneity related to cell-cycle status and cell location
脂质挑战配体以调控受体
Lipids challenge ligands to control receptors
抑制PRMT活性增强同源重组功能正常的卵巢癌和乳腺癌细胞对PARP抑制剂的敏感性
Repression of PRMT activities sensitize human homologous recombination-proficient ovarian and breast cancer cells to PARP inhibitor treatment