深度学习将机制模型与单细胞转录组数据关联,揭示DNA损伤下的转录爆发现象。
Deep learning linking mechanistic models to single-cell transcriptomics data reveals transcriptional bursting in response to DNA damage
生物技术与制药领域的最新动态
Deep learning linking mechanistic models to single-cell transcriptomics data reveals transcriptional bursting in response to DNA damage
SLC4A1 mutations that cause distal renal tubular acidosis alter cytoplasmic pH and cellular autophagy
Correction: Opposing p53 and mTOR/AKT promote an in vivo switch from apoptosis to senescence upon telomere shortening in zebrafish
Acetylation of H3K115 is associated with fragile nucleosomes at CpG island promoters and active regulatory sites
Ancient photoreceptor shapes behavioural responses
Intracellular expression of a fluorogenic DNA aptamer using retron Eco2
Sperm motility in mice with oligo-astheno-teratozoospermia restored by in vivo injection and electroporation of naked mRNA
Dissociable dynamic effects of expectation during statistical learning
Toward neuroanatomical and cognitive foundations of macaque social tolerance grades
Raw signal segmentation for estimating RNA modification from Nanopore direct RNA sequencing data
JAX Animal Behavior System (JABS), a genetics-informed, end-to-end advanced behavioral phenotyping platform for the laboratory mouse
Agent-based modeling reveals how bats navigate dense group emergences
Resolving synaptic events using subsynaptically targeted GCaMP8 variants
A sense of direction
Rift Valley fever virus dynamics in a transhumant cattle system in The Gambia
Genetic network shaping Kenyon cell identity and function in Drosophila mushroom bodies
Coordinated stimulation of axon regenerative and neurodegenerative transcriptional programs by ATF4 following optic nerve injury
Massively parallel reporter assay for mapping gene-specific regulatory regions at single-nucleotide resolution
Flexible neural representations of abstract structural knowledge in the human entorhinal cortex
Synthetic gene circuits that selectively target RAS-driven cancers