Structural basis of regulated N-glycosylation at the secretory translocon

Nature, Published online: 19 November 2025; doi:10.1038/s41586-025-09756-8The structural mechanism of a natively isolated GRP94 folding intermediate tethered to a CCDC134-bound translocon is described, revealing how the nascent chain remodels the translocon to control N-glycosylation by OST.