by Daniel S. Kluger, Teresa Berther, Martina Saltafossi, Jana Fehring, Joachim Gross The field of interoception research is growing at a rapid pace. We need to establish mechanistic insight into brain–body interactions and validate readouts before we can develop effective body-based health interventions. The field of interoception research is growing at a rapid pace. This Perspective highlights why establishing both mechanistic insight and construct validity will be critical prerequisites for