by Fengyi Mao, Sai Wu, Derek B. Allison, Daheng He, Yifan Kong, Chaohao Li, Zhiguo Li, Yanquan Zhang, Xinyi Wang, Qiongsi Zhang, Chi Wang, Xiaoqi Liu
Polo-like kinase 1 (PLK1), a critical cell cycle regulator, is associated with cancer progression and negatively correlates with patient survival in cutaneous melanoma based on clinical database analysis. In a melanoma mouse model induced by BRafCA mutation and Pten-deficiency, we observed that PLK1 overexpression mediated metabolic reprogramming