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转录组学与蛋白质组学分析揭示氮循环是原绿球藻长期生存的核心机制
Prochlorococcus, the dominant cyanobacterium in the oligotrophic ocean, possesses a streamlined genome and depends on interactions with heterotrophic bacteria for survi...
高致病性禽流感A(H5)病毒分支2.3.2.1c和2.3.4.4持续进化导致血凝素基因分支命名更新
The evolutionary divergence of the A(H5) hemagglutinin (HA) gene of high pathogenicity avian influenza (HPAI) viruses (A/goose/Guangdong/96 lineage) was analyzed by phy...
揭示公共与私有T细胞受体识别肽的结构决定因素
Public T cell receptors (TCRs) recurrently emerge across individuals in response to common pathogens, yet the structural and biophysical basis distinguishing public fro...
热与非热应激条件激活恶性疟原虫AP2-HS依赖性热休克反应
To preserve proteome homeostasis and survive at higher-than-optimal temperatures, organisms have evolved the conserved heat shock (HS) response (HSR), characterised by...
针对牛病原体莫拉氏菌的新型噬菌体特性研究
Background: Infectious bovine keratoconjunctivitis is the most important cattle ocular disease worldwide. The infection is primarily caused by Moraxella bovis and is a...
果蝇tRNA库进化中性别偏向性重复快速产生
Eukaryotic genomes encode hundreds of transfer RNA genes ostensibly to ensure efficient translation. How these seemingly redundant tRNA copies arise and are naturally s...
通用大语言模型如DeepSeek V3.2已进化出蛋白质设计能力
General-Purpose Large Language Models (GLLMs), although primarily developed for natural language processing, are increasingly demonstrating emergent capabilities in spe...
mRNA衰变率的生物物理限制塑造稳态丰度中的宏观进化差异
Evolutionary changes to gene expression are understood to be a major driver of phenotypic divergence between species. Researchers have investigated the drivers of this...
甘油通过非转录机制抑制化脓链球菌的乳糖依赖性生长
Streptococcus pyogenes (group A Streptococcus; GAS) requires flexible metabolic regulation to adapt to diverse host environments; however, its physiological responses t...
噬菌体全基因组转座子诱变
Bacteriophages have genomes that span a wide size range, are densely packed with coding sequences, and frequently encode genes of unknown function. Classical forward ge...
细菌免疫系统：微生物组结构的成因与结果
by Rafael Custodio, Ellinor O. Alseth, Michael A. Brockhurst, Sam P. Brown, Edze R. Westra Attacks from molecular parasites such as mobile genetic elements (MGEs) have...
瞬时基因熔融调控少突胶质细胞成熟时机
Publication date: 30 October 2025Source: Cell, Volume 188, Issue 22Author(s): Kevin C. Allan, Jesse J. Zhan, Andrew R. Morton, Erin F. Cohn, Marissa A. Scavuzzo, Anushk...
人类高级别浆液性卵巢癌的综合蛋白质基因组学特征分析
Publication date: Available online 4 November 2025Source: CellAuthor(s): Hui Zhang, Tao Liu, Zhen Zhang, Samuel H. Payne, Bai Zhang, Jason E. McDermott, Jian-Ying Zhou,...
SNARE蛋白在巨自噬过程中不可或缺
Publication date: 13 November 2025Source: Cell, Volume 188, Issue 23Author(s): Usha Nair, Anjali Jotwani, Jiefei Geng, Noor Gammoh, Diana Richerson, Wei-Lien Yen, Janic...
与RFK Jr.的“健康思想交流”如何推动了FDA的基因疗法进程
When Tim Hunt was invited to a meeting with Robert F. Kennedy Jr. in early March, the Department of Health and Human Services secretary had only been sworn in a few wee...
吉列德突然与总法律顾问分道扬镳
Gilead’s general counsel and EVP of corporate affairs Deborah Telman will hang up the gloves by Dec. 5, the company announced in a brief filing Nov. 15. Gilead didn’t o...
人工智能面临民主困境，原因在此
Nature, Published online: 18 November 2025; doi:10.1038/d41586-025-03718-wA thorough examination of artificial intelligence’s promise in politics rests on a thorny prem...
停止无稽之谈：基因编辑产生具有潜在治疗作用的转移RNA
Nature, Published online: 19 November 2025; doi:10.1038/d41586-025-03587-3Genome editing has been used to generate a type of transfer RNA that overcomes the harmful eff...