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人类结膜上皮细胞与巨噬细胞对沙眼衣原体A、B基因型在感染早中期周期反应的比较转录组分析
Chlamydia trachomatis (Ct), an obligate intracellular bacterium, is the primary infectious cause of blindness through trachoma. Ct undergoes a unique biphasic developme...
结核病患者肠道微生物组中双歧杆菌与大肠杆菌主导的生态群塑造独特的微生物代谢特征
Introduction Gut microbial community plays a key role in maintaining host immune homeostasis. However, current analytical approaches treat microbiomes at taxon-level an...
构建高效中心代谢途径，提升酵母生物合成能力且不抑制细胞生长
Long-term natural evolution selects glycolysis as the major metabolic mode for rapid cell growth, which however lacks sufficient NADPH supply to dive the biosynthesis o...
地热变形虫刷新真核生物生存温度上限
The study of temperature limits has transformed our knowledge of the boundaries of life but has been largely focused on bacteria and archaea. We isolated a novel geothe...
针对代谢弱点：缬氨霉素增强生物能量抑制剂对抗耐药与休眠结核分枝杆菌的效力
Tuberculosis (TB) treatment is hampered by monotherapy limitations and phenotypic drug tolerance, citing the need for effective drug combinations. The mycobacterial ele...
转录组学与蛋白质组学分析揭示氮循环是原绿球藻长期生存的核心机制
Prochlorococcus, the dominant cyanobacterium in the oligotrophic ocean, possesses a streamlined genome and depends on interactions with heterotrophic bacteria for survi...
高致病性禽流感A(H5)病毒分支2.3.2.1c和2.3.4.4持续进化导致血凝素基因分支命名更新
The evolutionary divergence of the A(H5) hemagglutinin (HA) gene of high pathogenicity avian influenza (HPAI) viruses (A/goose/Guangdong/96 lineage) was analyzed by phy...
人类星状病毒中病毒蛋白酶介导的多聚蛋白加工
Positive-sense RNA viruses often encode large polyproteins that are proteolytically processed by viral and host proteases into functional replication proteins. Astrovir...
揭示公共与私有T细胞受体识别肽的结构决定因素
Public T cell receptors (TCRs) recurrently emerge across individuals in response to common pathogens, yet the structural and biophysical basis distinguishing public fro...
仲裁系统通过调控小抗阻遏蛋白来控制裂解/溶原性决策
Many temperate Bacillus phages utilize the arbitrium signaling system to control lysis/lysogeny decisions. While the function of the arbitrium signal AimP and its recep...
热与非热应激条件激活恶性疟原虫AP2-HS依赖性热休克反应
To preserve proteome homeostasis and survive at higher-than-optimal temperatures, organisms have evolved the conserved heat shock (HS) response (HSR), characterised by...
石胆酸诱导依赖T3SS形成具有侵袭能力的福氏志贺氏菌聚集物
Shigella flexneri causes shigellosis, the second leading cause of diarrheal deaths worldwide. The pathogen invades colonic epithelial cells using a type III secretion s...