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bioRxiv Nov 25, 2025

Transcriptomic and Proteomic Analysis Reveals Nitrogen Recycling as a Core Mechanism for Prochlorococcus Prolonged Survival

Prochlorococcus, the dominant cyanobacterium in the oligotrophic ocean, possesses a streamlined genome and depends on interactions with heterotrophic bacteria for survi...

#Core Mechanism #Reveals Nitrogen #Nitrogen Recycling #Prolonged Survival

bioRxiv Nov 25, 2025

Nomenclature updates to the hemagglutinin gene clade designations resulting from the continued evolution of high pathogenicity avian influenza A(H5) virus clades 2.3.2.1c and 2.3.4.4

The evolutionary divergence of the A(H5) hemagglutinin (HA) gene of high pathogenicity avian influenza (HPAI) viruses (A/goose/Guangdong/96 lineage) was analyzed by phy...

#high pathogenicity #pathogenicity avian #avian influenza #Nomenclature updates

bioRxiv Nov 25, 2025

Uncovering structural determinants of peptide recognition by public and private T-cell receptors

Public T cell receptors (TCRs) recurrently emerge across individuals in response to common pathogens, yet the structural and biophysical basis distinguishing public fro...

#private T-cell #Uncovering structural #structural determinants #common pathogens

bioRxiv Nov 25, 2025

Thermal and non-thermal stress conditions activate the Plasmodium falciparum AP2-HS-dependent heat-shock response

To preserve proteome homeostasis and survive at higher-than-optimal temperatures, organisms have evolved the conserved heat shock (HS) response (HSR), characterised by...

#Plasmodium falciparum #HSR #heat shock #chaperone-encoding genes

bioRxiv Nov 25, 2025

Characterisation of novel bacteriophages against the cattle pathogen Moraxella bovis

Background: Infectious bovine keratoconjunctivitis is the most important cattle ocular disease worldwide. The infection is primarily caused by Moraxella bovis and is a...

#bovis Background #Infectious bovine #Moraxella bovis #pathogen Moraxella

bioRxiv Nov 25, 2025

Sex-biased duplicates are rapidly generated during Drosophila tRNA repertoire evolution

Eukaryotic genomes encode hundreds of transfer RNA genes ostensibly to ensure efficient translation. How these seemingly redundant tRNA copies arise and are naturally s...

#evolution Eukaryotic #transfer RNA #Eukaryotic genomes #RNA genes

bioRxiv Nov 25, 2025

General-Purpose Large Language Models, such as DeepSeek V3.2, Have Evolved Protein Design Capabilities

General-Purpose Large Language Models (GLLMs), although primarily developed for natural language processing, are increasingly demonstrating emergent capabilities in spe...

#Language Models #Large Language #language processing #General-Purpose Large

bioRxiv Nov 25, 2025

Biophysical constraints on mRNA decay rates shape macroevolutionary divergence in steady-state abundances

Evolutionary changes to gene expression are understood to be a major driver of phenotypic divergence between species. Researchers have investigated the drivers of this...

#major driver #divergence #Evolutionary #rates

bioRxiv Nov 25, 2025

Glycerol suppresses lactose-dependent growth of Streptococcus pyogenes through a transcription-independent mechanism

Streptococcus pyogenes (group A Streptococcus; GAS) requires flexible metabolic regulation to adapt to diverse host environments; however, its physiological responses t...

#Streptococcus pyogenes #Streptococcus #mechanism Streptococcus #requires flexible

bioRxiv Nov 25, 2025

Bacteriophage genome-wide transposon mutagenesis

Bacteriophages have genomes that span a wide size range, are densely packed with coding sequences, and frequently encode genes of unknown function. Classical forward ge...

#Bacteriophage genome-wide #mutagenesis Bacteriophages #size range #coding sequences

PLoS Biology Nov 25, 2025

Bacterial immune systems as causes and consequences of microbiome structure

by Rafael Custodio, Ellinor O. Alseth, Michael A. Brockhurst, Sam P. Brown, Edze R. Westra Attacks from molecular parasites such as mobile genetic elements (MGEs) have...

#Rafael Custodio #Westra Attacks #immune systems #Bacterial immune

Cell Nov 25, 2025

Transient gene melting governs the timing of oligodendrocyte maturation

Publication date: 30 October 2025Source: Cell, Volume 188, Issue 22Author(s): Kevin C. Allan, Jesse J. Zhan, Andrew R. Morton, Erin F. Cohn, Marissa A. Scavuzzo, Anushk...

#Anushka Nikhil #Publication date #maturation Publication #Transient gene

Cell Nov 25, 2025

Integrated Proteogenomic Characterization of Human High-Grade Serous Ovarian Cancer

Publication date: Available online 4 November 2025Source: CellAuthor(s): Hui Zhang, Tao Liu, Zhen Zhang, Samuel H. Payne, Bai Zhang, Jason E. McDermott, Jian-Ying Zhou,...

#Tao Liu #Hui Zhang #Zhen Zhang #Bai Zhang

Cell Nov 25, 2025

SNARE Proteins Are Required for Macroautophagy

Publication date: 13 November 2025Source: Cell, Volume 188, Issue 23Author(s): Usha Nair, Anjali Jotwani, Jiefei Geng, Noor Gammoh, Diana Richerson, Wei-Lien Yen, Janic...

#Usha Nair #Anjali Jotwani #Jiefei Geng #Noor Gammoh

FierceBiotech Nov 25, 2025

<a href="https://www.fiercebiotech.com/biotech/how-healthy-exchange-ideas-rfk-jr-kicked-fdas-gene-therapy-push" hreflang="en">How a 'healthy exchange of ideas' with RFK Jr. kick-started FDA's gene therapy push</a>

When Tim Hunt was invited to a meeting with Robert F. Kennedy Jr. in early March, the Department of Health and Human Services secretary had only been sworn in a few wee...

#Tim Hunt #Human Services #early March #kick-started FDA

FierceBiotech Nov 25, 2025

<a href="https://www.fiercebiotech.com/biotech/chutes-ladders-gilead-abruptly-parts-ways-general-counsel" hreflang="en">Chutes & Ladders—Gilead abruptly parts ways with general counsel</a>

Gilead’s general counsel and EVP of corporate affairs Deborah Telman will hang up the gloves by Dec. 5, the company announced in a brief filing Nov. 15. Gilead didn’t o...

#Deborah Telman #filing Nov. #Gilead abruptly #general counsel

Nature News Nov 25, 2025

AI has a democracy problem — here’s why

Nature, Published online: 18 November 2025; doi:10.1038/d41586-025-03718-wA thorough examination of artificial intelligence’s promise in politics rests on a thorny prem...

#Published online #thorny premise #information system #democracy problem

Nature News Nov 25, 2025

Stop the nonsense: genome editing creates potentially therapeutic transfer RNAs

Nature, Published online: 19 November 2025; doi:10.1038/d41586-025-03587-3Genome editing has been used to generate a type of transfer RNA that overcomes the harmful eff...

#Published online #RNAs Nature #nonsense’ gene #gene variants

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