by Ana Sánchez-Molina, Manuel Bernal, Joel D. Posligua-García, Antonio J. Pérez-Pulido, Laura de Cubas, Elena Hidalgo, M. -Henar Valdivieso, Silvia Salas-Pino, Rafael R. Daga The endoplasmic reticulum (ER) lumen provides the proper redox environment for disulfide bond formation, which is essential for the correct folding of proteins entering the secretory pathway and forming membranes. However, the precise mechanisms by which disruptions in protein folding within the ER activate proteostatic me